5/4/2023 0 Comments Blinded me with science tab![]() 2, 3 In addition, faster recovery of aerobic metabolism and better viability of mitochondria have been shown in isolated rat hearts pretreated with thiamine before global ischemia–reperfusion injury. Two studies investigating the effect of thiamine in septic shock and patients undergoing cardiac surgery showed no effect with regard to lactate levels however, increased oxygen consumption was demonstrated with thiamine supplementation in the cardiac surgery population. 1 The rate‐limiting enzyme, pyruvate dehydrogenase, couples glycolysis to the aerobic carbohydrate metabolism, and dysfunction of this enzyme can lead to elevated lactate levels. Thiamine (vitamin B1) is an essential cofactor for the pyruvate dehydrogenase complex function. The results of this study do not suggest a neuroprotective effect of thiamine following cardiac arrest There was no absolute mean group difference in lactate during the intensive care period (1.1 mmol/L P=0.16). Likewise, there were no absolute difference in neurological deficit score at the end of the protocol (2 P=0.93). Mean area under the curve for neuron‐specific enolase was similar between groups, with 81.5 μg/L per hour (SD, 20.4) in the thiamine group and 80.5 μg/L per hour (SD, 18.3) in the placebo group, with an absolute difference of 1.0 (95% CI, −57.8 to 59.8 P=0.97). ![]() Nine pigs were included in both groups, with 8 in each group surviving the entire intensive care phase. All pigs underwent 40 hours of intensive care and were awakened for assessment of functional neurological outcome up until 9 days after cardiac arrest. Twenty minutes after successful resuscitation, the pigs were randomized to treatment with either thiamine or placebo. Pigs underwent myocardial infarction and subsequently 9 minutes of untreated cardiac arrest. Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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